Colorectal cancer is the 2nd leading cause of cancer-related deaths in the world.The mechanisms underlying CRC development, progression, and resistance to treatment are complex and not fully understood.The immune response in the tumor microenvironment has been shown to play a significant role in many cancers, including colorectal cancer.Colony-stim
The Optimization Model of Runway and Gate Assignment
This paper is aimed to develop the optimization model of time slot utilization for both runway and apron gate of airport system.The model considers the objectives of Medical Tape airline company to minimize flight-taxiing-time and waiting-time for both landing and take-off.The optimization makes use of Network Representation (NR) in the form of two
Rab2 drives axonal transport of dense core vesicles and lysosomal organelles
Summary: Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs), endolysosomal organelles, and presynaptic components is critical for maintaining neuronal functionality.How the transport of DCVs is orchestrated remains an important unresolved question.The small GTPase Rab2 mediates DCV biogenesis and endosome-lysosome fusion.He
Struggling to decolonise ourselves as an antiracist act within the field of the Nordic Community School of Music and Arts
This article will investigate a general concern with the practical implementation of inclusion as recommended in policy documents in art education in general and the Nordic Community School of Music and Arts (NCSMA) specifically.We ask: What do policy documents mean by inclusion? In what way can or do art educators practice inclusionary strategies?
Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells
Abstract Bis(monoacylglycero)phosphate (BMP) is a major phospholipid constituent of intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation and sorting of lipid cargo.Recent observations suggest that the Batten disease-associated protein CLN5 functions as lysosomal BMP synthase.Here, we show that transacylation reacti